نقش زیر مجموعه های مونوسیت های خون محیطی در پیشرفت ضایعه آترواسکلروز عروق کرونر
نویسندگان
چکیده مقاله:
Background and purpose: Circulating monocytes are divided into different subpopulations according to the expression of CD14 and CD16. In this study, we investigated the correlation between the severity of coronary artery disease (CAD) and the frequency of two monocyte subsets and also expression level of CCR1 receptor on these monocytes. Materials and methods: The study was conducted in 88 patients who underwent diagnostic coronary angiography (CAG) in Tehran Shahid Rajaee Heart Center, 2014-2015. The participants were selected using convenience sampling. They were divided into four groups: 50% stenosis in one vessel (MVD), single vessel stenosis (1VD), 2 or 3 vessels stenosis (2+3 VD), and no CAD as the control group. The severity of CAD was evaluated by Gensini score. Frequency of the two monocyte subsets, including classical (CD14+CD16-) and non-classical (CD14+CD16+) were measured by flow cytometry. Mean fluorescence intensity (MFI) of CCR1 receptor on monocyts was also measured in two subsets and all groups of patients. Results: Circulating non-classical monocytes were observed more frequently in patients with 2+3 VD than in controls, MVD, and 1VD groups, but the differences were not statistically significant (P> 0.05). Both classical and non-classical monocytes expressed CCR1, but it was expressed on higher number of classical monocytes than in non-classical ones. Also, no significant differences were seen in MFI of CCR1 in different groups. Conclusion: This study showed that higher frequency of non-classical monocytes was correlated with severity of CAD.
منابع مشابه
ارتباط بین سلول های سفید خون و زیر رده های آن با آترواسکلروز عروق کرونر
Background and Aim: Many studies have shown a positive relationship between inflammatory factors and coronary artery disease (CAD). It has been proved that the total white blood cell count is an independent risk factor for CAD.A few studies have revealed the relationship between differential white blood cell count and CAD. The aim of this study was to investigate the correlations between corona...
متن کاملارتباط بین سلول های سفید خون و زیر رده های آن با آترواسکلروز عروق کرونر
زمینه و هدف: مطالعات متعددی ارتباط بین عوامل التهابی مختلف با بیماری عروق کرونر را مورد بررسی قرار داده اند. نشان داده شده که سلول های سفید خون محیطی، عامل خطر مستقل بیماری عروق کرونر هستند. مطالعات کمی ارتباط زیر رده های سلول های سفید با بیماری عروق کرونر را مورد بررسی قرار داده اند. مطالعه حاضر با هدف تعیین ارتباط بین سلول های سفید و زیر رده های آن با وجود و شدت آترواسکلروز عروق کرونر انجام ش...
متن کاملخصومت، خشم و خطر بروز آترواسکلروز عروق کرونر
Introduction: The previous researches about the etiology of coronary artery atherosclerosis have accentuated on clinical and medical risk factors, such as cigarette smoking, hypertension, diabetes mellitus, hyperlipidemia, positive family background, myocardial ischemia history in family, atherogenic diet, increase of A lipoprotein, inflammatory factors such as increase of cross-reactive protei...
متن کاملاثر EDTA بر آترواسکلروز عروق کرونر و عملکرد بطن چپ
Background and purpose : CAD is the most important cause of mortality and morbidity in all orer the world. Aim of this study was to determine the effect of EDTA on the process of atherosclerosis. Materials and methods : The study is a randomized clinical trial. 14 patients whom were not suitable candidates for mechanical- Revascularization(PCI or CABG), were treated with EDTA injection twi...
متن کاملنقش پروتئین فاز حاد و سلول‌های سفید خون محیطی در پیش‌گویی حوادث عروق کرونر در مبتلایان به آنژین صدری ناپایدار
Background: Unstable angina is a critical phase of coronary heart disease with widely variable symptoms and prognosis. In recent years, the pathophysiological roles of platelet activation and inflammation in unstable angina have been elucidated. The main aim of this study was to evaluate the role of C-reactive protein (CRP) and neutrophil count as predictive factors for future events (in a six...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 28 شماره 166
صفحات 30- 39
تاریخ انتشار 2018-11
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023